Current approaches to flexible loop modeling

Loops are key components of protein structures, involved in many biological functions. Due to their conformational variability, the structural investigation loops is a difficult topic, requiring combination experimental and computational methods. This paper provides brief overview current approaches flexible loop modeling, presents main ingredients most standard protocols. Despite great progress recent years, accurately modeling variability long remains challenging problem. Future advances this field will likely come from tight coupling techniques, which would enable better understanding relationships between sequence, flexibility, functional roles. In fine, accurate open road design problems interest for applications biomedicine biotechnology.